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KMID : 0620920080400010052
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Experimental & Molecular Medicine
2008 Volume.40 No. 1 p.52 ~ p.58
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Rutin inhibits osteoclast formation by decreasing reactive oxygen species and TNF-α by inhibiting activation of NF-κB
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Kyung Tae-Wook
Lee Ji-Eun
Shin Hyun-Hee
Choi Hye-Seon
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Abstract
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Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-κ B ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-α . Rutin also lowers NF-κ B activation in response to RANKL.
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KEYWORD
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macrophages, NF-κB, osteoclasts, RANK ligand, reactive oxygen species, rutin, tumor necrosis factor α
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